Bioactive Implants for Prophylaxis and Treatment of Biomedical Device Related Infections

The present invention is a method for coating medical and orthopaedic devices with novel coating(s) that may provide beneficial characteristics. This method provides the ability to coat a medical device wherein one or more bioactive agents are impregnated in the coating. A further aspect of the present invention is the ability to impregnate low molecular weight (MW) ionic bioactive molecules by post-treatment of a multilayer on a biomedical device. Additionally, high MW bioactive agents may be incorporated using a carrier such as a protein that may facilitate the incorporation while also protecting the bioactivity of the agent. High MW bioactive agents can be more easily incorporated into a coating that is ultrathin compared to currently available techniques. An additional aspect of the present invention is the means to control the release rate of impregnated bioactive agent(s) through control of the multilayer coating(s). The invention also enables the creation of an extra-cellular-matrix (ECM)-like fibrillar network structure made of non-ECM components and the incorporation of IL-12 at the implant/tissue interface.

Intellectual Property Status
Disclosure 368. Patent Pending

Inventors
Bingyun Li, Bingbing Jiang, Brock Lindsey, Sanford Emery